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                    miltenyi美天旎Human IL-2 IS細胞因子

                    • 更新時間:  2023-07-26
                    • 產(chǎn)品型號:  130-097-748
                    • 簡單描述
                    • miltenyi美天旎Human IL-2 IS細胞因子
                      品牌:Miltenyi(美天旎)
                      貨號:130-097-748
                      CAS號:詳見說明書
                      供應(yīng)商:Miltenyi(美天旎)
                      保質(zhì)期:詳見說明書
                      保存條件:詳見說明書
                      規(guī)格:EA
                    詳細介紹

                    miltenyi美天旎Human IL-2 IS細胞因子miltenyi美天旎Human IL-2 IS細胞因子

                    IL-2 IS stands for interleukin 2 "Improved Sequence", also termed aldesleukin, and is a variant of IL-2 with a serine to cysteine substitution. Human IL-2 IS is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays, and possesses the same properties as naturally occurring IL-2.

                    Background information

                    IL-2, a potent lymphoid cell growth factor, is a typical four α-helix bundle cytokine. It is produced by activated T cells, especially the CD4+ T helper cell population. It plays an important role in both the activation and maintenance of immune responses and in lymphocyte development. IL-2 promotes proliferation and differentiation of T cells, NK cells and B cells and is involved in the elimination of self-reactive T cells. IL-2 signals through a receptor complex consisting of IL-2 receptor α-chain (CD25), β- chain, and common γ-chain. The latter two are also used for IL-15 signaling.

                    Biological activity

                    Proliferation of CTLL-2 cells (NIBSC 86/504)

                    research grade: ≥ 3×106 IU/mg

                    premium grade: ≥ 5×106 IU/mg

                    Quality description

                    Research-grade cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

                    Premium-grade cytokines offer the convenience of high and well-defined biological activities and allow exact unit dosing for demanding applications. The biological activity is determined after lyophilization and reconstitution, and normalized to WHO/NIBSC standards whenever available. In general, endotoxin levels are <0.01 ng/μg (<0.1 EU/μg), and purities are >97%. Lot-specific certificates of analysis are available on request (macstec@miltenyibiotec.de).


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